BDBM50095470 CHEMBL3590474::US10155765, Example 9

SMILES Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(n1)C(N)=O

InChI Key InChIKey=SSMUXZNGWKTWKM-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50095470   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck

Curated by ChEMBL

LigandBDBM50095470(CHEMBL3590474 | US10155765, Example 9)Copy SMILESCopy InChI

Affinity DataIC50: 0.300nMAssay Description:Inhibition of human IRAK4 assessed as phosphorylation of fluorescent peptide substrate after 30 mins by fluorescent polarization readerMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/17/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck

Curated by ChEMBL

LigandBDBM50095470(CHEMBL3590474 | US10155765, Example 9)Copy SMILESCopy InChI

Affinity DataIC50: 0.400nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/10/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL