BDBM50095535 CHEMBL3590517::US10329294, Example 177

SMILES Cn1cc(NC(=O)c2cnn3ccc(nc23)N2CC[C@H](F)[C@@H](N)C2)c(n1)C(F)(F)F

InChI Key InChIKey=KGUMLEANDLMCCI-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50095535   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck

Curated by ChEMBL

LigandBDBM50095535(CHEMBL3590517 | US10329294, Example 177)Copy SMILESCopy InChI

Affinity DataIC50: 6nMAssay Description:Inhibition of human IRAK4 assessed as phosphorylation of fluorescent peptide substrate after 30 mins by fluorescent polarization readerMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/17/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck

Curated by ChEMBL

LigandBDBM50095535(CHEMBL3590517 | US10329294, Example 177)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/31/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL