BDBM50095585 1-(4-Butoxy-benzenesulfonyl)-4-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-pyrrolidine-2-carboxylic acid hydroxyamide::CHEMBL423015

SMILES CCCCOc1ccc(cc1)S(=O)(=O)N1C[C@H](C[C@@H]1C(=O)NO)N1C(=O)NC(C)(C)C1=O

InChI Key InChIKey=QGTWMCXPSZIGIN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50095585   

Target72 kDa type IV collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095585(1-(4-Butoxy-benzenesulfonyl)-4-(4,4-dimethyl-2,5-d...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against matrix metalloprotease -2 (gelatinase-A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095585(1-(4-Butoxy-benzenesulfonyl)-4-(4,4-dimethyl-2,5-d...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibitory activity against matrix metalloprotease -3 (stromelysin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50095585(1-(4-Butoxy-benzenesulfonyl)-4-(4,4-dimethyl-2,5-d...)
Affinity DataIC50: 447nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50095585(1-(4-Butoxy-benzenesulfonyl)-4-(4,4-dimethyl-2,5-d...)
Affinity DataIC50: 450nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-7 (matrilysin, MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095585(1-(4-Butoxy-benzenesulfonyl)-4-(4,4-dimethyl-2,5-d...)
Affinity DataIC50: 780nMAssay Description:In vitro inhibitory activity against matrix metalloprotease -1 (collagenase-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed