BDBM50096858 CHEMBL3580767

SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCOc3ccc(F)c4nc(sc34)C(F)(F)F)CCn2c1=O

InChI Key InChIKey=YQSXKNVPEQLXJQ-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50096858   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50096858(CHEMBL3580767)Copy SMILESCopy InChI

Affinity DataIC50: 25nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/21/2016
Entry Details Article
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