BDBM50097007 4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol::CHEMBL10931

SMILES Cc1cc(C)cc(c1)-c1[nH]c2ccccc2c1CCNCCCCc1ccc(O)cc1

InChI Key InChIKey=PACZUAOKBGMJAN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50097007   

TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50: 27nMAssay Description:Inhibition of rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50: 27nMAssay Description:Inhibition of rat GnRH receptor bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50: 50nMAssay Description:Ability to displace [125I]- - radio-labeled buserelin from rat Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50: 50nMAssay Description:Binding affinity to rat Gonadotropin-releasing hormone receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50: 50nMAssay Description:Inhibition of [125I]buserelin binding to rat pituitary Gonadotropin-releasing hormone receptor, in the absence of bovine serum albumin (BSA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50: 357nMAssay Description:Inhibitory activity evaluated against human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50: 357nMAssay Description:Inhibition of human Gonadotropin-releasing hormone receptor bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition GnRH-stimulated luteinizing hormone (LH) release from rat pituitary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed