BDBM50097364 3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one::3-Imidazol-1-ylmethyl-xanthen-9-one::CHEMBL350922

SMILES O=c1c2ccccc2oc2cc(Cn3ccnc3)ccc12

InChI Key InChIKey=GFCUIFVKCOEHQN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50097364   

TargetAromatase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097364(3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one | 3-...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human placental microsome cytochrome P450 19A1 aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097364(3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one | 3-...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097364(3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one | 3-...)
Affinity DataIC50: 390nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097364(3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one | 3-...)
Affinity DataIC50: 71nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPTLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097364(3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one | 3-...)
Affinity DataIC50: 344nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate after 30 mins by HPTLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed