BDBM50097401 CHEMBL3586459::US9856257, 3

SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1

InChI Key InChIKey=JPNWAWNQSJRXQR-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50097401   

TargetMicrotubule-associated protein 2(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50097401(CHEMBL3586459 | US9856257, 3)Copy SMILESCopy InChI

Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assayMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/21/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetMethionine aminopeptidase 2(Human)
Sanofi

US Patent

LigandBDBM50097401(CHEMBL3586459 | US9856257, 3)Copy SMILESCopy InChI

Affinity DataIC50: 24nMAssay Description:For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/21/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL