BDBM50097960 2-{3-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-pyrrolidin-1-yl}-acetamide::CHEMBL355322

SMILES COc1cccc(c1)-c1cn(C2CCN(CC(N)=O)C2)c2ncnc(N)c12

InChI Key InChIKey=SRVDBASMNUCPHD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50097960   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097960(2-{3-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]p...)
Affinity DataIC50: 38nMAssay Description:Inhibition of p60 c-Src tyrosine kinase enzyme activity in liquid-phase tyrosine phosphorylation assay at 830 ng/mLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097960(2-{3-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]p...)
Affinity DataIC50: 440nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097960(2-{3-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]p...)
Affinity DataIC50: 700nMAssay Description:Concentration required for inhibition of v-Abl receptor by tyrosine kinase enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097960(2-{3-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]p...)
Affinity DataIC50: 5.00E+3nMAssay Description:Concentration required for inhibition of c-Src mediated phosphorylation of Fak in IC8.1 fibroblast cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed