BDBM50097991 CHEMBL355019::{3-[4-Amino-5-(3-hydroxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-pyrrolidin-1-yl}-acetic acid methyl ester

SMILES COC(=O)CN1CCC(C1)n1cc(-c2cccc(O)c2)c2c(N)ncnc12

InChI Key InChIKey=NMCRRFLWJZUPRE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50097991   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097991({3-[4-Amino-5-(3-hydroxy-phenyl)-pyrrolo[2,3-d]pyr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of p60 c-Src tyrosine kinase enzyme activity in liquid-phase tyrosine phosphorylation assay at 830 ng/mLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097991({3-[4-Amino-5-(3-hydroxy-phenyl)-pyrrolo[2,3-d]pyr...)
Affinity DataIC50: 54nMAssay Description:Concentration required for inhibition of v-Abl receptor by tyrosine kinase enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097991({3-[4-Amino-5-(3-hydroxy-phenyl)-pyrrolo[2,3-d]pyr...)
Affinity DataIC50: 700nMAssay Description:Concentration required for inhibition of c-Src mediated phosphorylation of Fak in IC8.1 fibroblast cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097991({3-[4-Amino-5-(3-hydroxy-phenyl)-pyrrolo[2,3-d]pyr...)
Affinity DataIC50: 740nMAssay Description:Concentration required for inhibition of epidermal growth factor receptor (EGF-R) by tyrosine kinase enzyme activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097991({3-[4-Amino-5-(3-hydroxy-phenyl)-pyrrolo[2,3-d]pyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of autophosphorylation of epidermal growth factor receptor (EGF-R) in a cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed