BDBM50098263 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-pent-4-ynoic acid::CHEMBL10454

SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(CC#Cc1ccccc1)C(O)=O

InChI Key InChIKey=UXURFMZZZWZYFW-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50098263   

TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 21nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 2.00E+3nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-1 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 12nMpH: 7.4Assay Description:Inhibitory activity against matrix metalloprotease-2 (MMP-2) in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 2.28E+3nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-3 (MMP-3) (at pH 7.4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 21nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 2.28E+3nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 9.40nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 553nMAssay Description:In vitro inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 12.5nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 1.96E+3nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 20.9nMAssay Description:Inhibitory activity against recombinant human matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed