BDBM50098276 2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-phenoxy-hex-4-ynoic acid::CHEMBL10952

SMILES OC(=O)C(CC#CCOc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1

InChI Key InChIKey=MWPVYUMZDJJEOU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50098276   

TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098276(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-phenoxy-he...)
Affinity DataIC50: 1.81E+3nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-3 (MMP-3) (at pH 7.4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098276(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-phenoxy-he...)
Affinity DataIC50: 1.00E+4nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-1 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098276(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-phenoxy-he...)
Affinity DataIC50: 254nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098276(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-phenoxy-he...)
Affinity DataIC50: 23nMpH: 7.4Assay Description:Inhibitory activity against matrix metalloprotease-2 (MMP-2) in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098276(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-phenoxy-he...)
Affinity DataIC50: 251nMAssay Description:Inhibitory activity against recombinant human matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed