BDBM50098956 5-Phenyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylamine::CHEMBL8106

SMILES NC1=NC(Cc2ccsc12)c1ccccc1

InChI Key InChIKey=OJTGYEZYCLLMBZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50098956   

TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098956(5-Phenyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylamin...)
Affinity DataIC50: 8.30E+3nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by i-NOS from human DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098956(5-Phenyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylamin...)
Affinity DataIC50: 140nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098956(5-Phenyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylamin...)
Affinity DataIC50: 4.00E+3nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed