BDBM50099587 2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol::CHEMBL44426::Pipendoxifene::US8815934, No. 107::US8815934, No. 97

SMILES Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc12

InChI Key InChIKey=JICOGKJOQXTAIP-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50099587   

TargetEstrogen receptor(Human)
Wyeth

US Patent
LigandPNGBDBM50099587(US8815934, No. 107 | CHEMBL44426 | US8815934, No. ...)
Affinity DataIC50: 60nMT: 2°CAssay Description:The competition assay was performed in a 96-well plate (polystyrene*) which binds <2.0% of the total input [3H]-17beta-estradiol and each data point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Wyeth

US Patent
LigandPNGBDBM50099587(US8815934, No. 107 | CHEMBL44426 | US8815934, No. ...)
Affinity DataIC50: 60nMT: 2°CAssay Description:The competition assay was performed in a 96-well plate (polystyrene*) which binds <2.0% of the total input [3H]-17beta-estradiol and each data point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Wyeth

US Patent
LigandPNGBDBM50099587(US8815934, No. 107 | CHEMBL44426 | US8815934, No. ...)
Affinity DataIC50: 1.5nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099587(US8815934, No. 107 | CHEMBL44426 | US8815934, No. ...)
Affinity DataIC50: 40nMAssay Description:In vitro inhibitory concentration against [3H]17-beta-estradiol binding to human estrogen receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Wyeth

US Patent
LigandPNGBDBM50099587(US8815934, No. 107 | CHEMBL44426 | US8815934, No. ...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition of [3H]17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Wyeth

US Patent
LigandPNGBDBM50099587(US8815934, No. 107 | CHEMBL44426 | US8815934, No. ...)
Affinity DataEC50:  0.100nMAssay Description:Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed