BDBM50099996 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-phenylsulfanyl-benzonitrile::CHEMBL439917

SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Sc3ccccc3)c2)CC1=O

InChI Key InChIKey=PKVZEFALNPNGOP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50099996   

LigandPNGBDBM50099996(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)
Affinity DataIC50: 255nMAssay Description:Concentration required to displace 50% of a radiolabeled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099996(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099996(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)
Affinity DataIC50: 1.80E+4nMAssay Description:In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed