BDBM50099997 2-(3-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL30349

SMILES Clc1cccc(Oc2cc(Cn3cncc3CN3CCN(C(=O)C3)c3cccc(Cl)c3)ccc2C#N)c1

InChI Key InChIKey=NGKWYAFKLLDUKM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50099997   

LigandPNGBDBM50099997(2-(3-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)
Affinity DataIC50: 93nMAssay Description:Concentration required to displace 50% of a radiolabeled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099997(2-(3-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099997(2-(3-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)
Affinity DataIC50: 2.00E+4nMAssay Description:In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed