BDBM50101921 19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide::CHEMBL50857

SMILES CN1c2cccc3ccc(Oc4cc(Cn5cncc5CC(=O)NCC1=O)ccc4C#N)cc23

InChI Key InChIKey=QJAYXHNDUQQSPN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50101921   

LigandPNGBDBM50101921(19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapen...)
Affinity DataIC50: 6.60nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101921(19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapen...)
Affinity DataIC50: 65nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101921(19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapen...)
Affinity DataIC50: 1.09E+3nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed