BDBM50102614 7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-6,10-dicarboxylic acid 6-hydroxyamide 10-methylamide::CHEMBL433381

SMILES CNC(=O)[C@@H]1CCc2ccc(OCCC[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO)cc2

InChI Key InChIKey=CFUYAVWBVRZFLA-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50102614   

TargetMatrix metalloproteinase-9(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102614(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptad...)
Affinity DataKi:  2.10nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102614(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptad...)
Affinity DataKi:  5.30nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102614(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptad...)
Affinity DataKi:  48nMAssay Description:Inhibition of human MMP-3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102614(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptad...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LPS-stimulated TNF-alpha release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed