BDBM50103248 5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL330638

SMILES COc1cccc2OC(c3cc(C)cc(C)c3)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=BFFNEJBHCHAMGY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50103248   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103248(5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 9.20nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103248(5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 18nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103248(5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 24nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103248(5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 146nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed