BDBM50103254 CHEMBL317578::Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-phenyl ester

SMILES COc1cccc2OC(c3cccc(OC(=O)N(C)C)c3)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=VAGCBEBNRFICRM-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50103254   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]- Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataIC50: 6nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataIC50: 12nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataIC50: 26nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataIC50: 216nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataKi:  3.07E+3nMAssay Description:Binding affinity for androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataKi:  3.91E+3nMAssay Description:Binding affinity for mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity for progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed