BDBM50103327 4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL318943

SMILES O=C1[C@H](CCN1Cc1ccccc1)N(CCc1ccccc1)Cc1cncn1Cc1ccc(cc1)C#N

InChI Key InChIKey=NGWHQWBIMKMHDC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50103327   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103327(4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-...)
Affinity DataIC50: 51nMAssay Description:In vitro inhibition of farnesyl transferase using purified recombinant human enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103327(4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-...)
Affinity DataIC50: 460nMAssay Description:Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103327(4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory concentration of geranylgeranyl-protein transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed