BDBM50103346 4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-(2-piperazin-1-yl-ethyl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101788

SMILES Clc1cccc(CN2CC[C@H](N(CCN3CCNCC3)Cc3cncn3Cc3ccc(cc3)C#N)C2=O)c1

InChI Key InChIKey=OAOZPXOXMVMQBZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50103346   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103346(4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]...)
Affinity DataIC50: 6.10nMAssay Description:In vitro inhibition of farnesyl transferase using purified recombinant human enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103346(4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]...)
Affinity DataIC50: 300nMAssay Description:Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103346(4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory concentration of geranylgeranyl-protein transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed