BDBM50104620 CHEMBL3593551

SMILES CCC[C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@@H](CC1CCCCC1)N1C[C@H](Cc2ccccc2)N(CCc2ccccc2)C(=O)C1=O

InChI Key InChIKey=ZEPWGRQYGKUKNA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50104620   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104620(CHEMBL3593551)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104620(CHEMBL3593551)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of ADAM17 in human THP1 cells assessed as inhibition of LPS-stimulated TNFalpha cleavage after 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104620(CHEMBL3593551)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP9 (unknown origin) using Mca-KLPGL-Dnp-AR as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104620(CHEMBL3593551)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP2 (unknown origin) using Mca-KLPGL-Dnp-AR as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104620(CHEMBL3593551)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP8 (unknown origin) using Mca-KLPGL-Dnp-AR as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104620(CHEMBL3593551)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP14 (unknown origin) using Mca-KLPGL-Dnp-AR as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104620(CHEMBL3593551)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ADAM10 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed