BDBM50104709 (R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)-2-(phenylsulfonamido)propanamide::2-Benzenesulfonylamino-N-[5-(4-cyano-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamide::CHEMBL111450

SMILES C[C@@H](NS(=O)(=O)c1ccccc1)C(=O)NC1=NN=C(CS1)c1ccc(cc1)C#N

InChI Key InChIKey=IIABJCHWKFZJBK-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50104709   

TargetMatrix metalloproteinase-9(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  80nMAssay Description:In vitro inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  210nMAssay Description:In vitro inhibitory activity against the catalytic domain of the human matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  210nMAssay Description:In Vitro inhibitory activity against the catalytic domain of the matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  230nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  240nMAssay Description:Inhibition of matrix metalloprotease-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  360nMAssay Description:In Vitro inhibitory activity against the catalytic domain of the matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  363nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  400nMAssay Description:In vitro inhibitory activity against the ectodomain of the human matrix metalloproteinase-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
UniversitäT Bielefeld

Curated by ChEMBL
LigandPNGBDBM50104709((R)-N-(5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl)...)
Affinity DataKi:  400nMAssay Description:In vitro inhibitory activity against the catalytic domain of the human matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed