BDBM50104963 (2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-3-(3-hydroxybenzyl)succinamide::(3R)-N~2~-(cyclopropylmethyl)-N~1~-hydroxy-3-(3-hydroxybenzyl)-N~4~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-L-aspartamide::(R)-2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydroxy-benzyl)-N*4*-((3S,3aR)-2-hydroxy-indan-1-yl)-succinamide::2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydroxy-benzyl)-N*4*-(2-hydroxy-indan-1-yl)-succinamide::CHEMBL24398

SMILES ONC(=O)[C@@H](NCC1CC1)[C@@H](Cc1cccc(O)c1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12

InChI Key InChIKey=UACUZULRKJKTHE-UHFFFAOYSA-N

Data  13 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50104963   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant aggrecanase 1 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human ADAMTS-5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human ADAMTS-4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant ADAMTS5 expressed in HEK293 cells using Abz-TESEwSRGAIY-Dpa-KK as substrate measured for 2 hrs by fluorometric analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant ADAMTS4 expressed in HEk293 cells using FAM-AEwLQGRPISIAK-TAMRA as substrate measured for 15 mins by fluorometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant TACE after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MMP1 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  171nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  171nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  321nMAssay Description:Inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  4.47E+3nMAssay Description:Inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  4.47E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  4.47E+3nMAssay Description:Affinity for Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  6.30E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  6.30E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  3.32E+4nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963(2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydr...)
Affinity DataKi:  3.32E+4nMAssay Description:Inhibition of matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed