BDBM50105619 1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl)-urea::1-(5-tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)urea::CHEMBL94487

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1

InChI Key InChIKey=ANWRKPQVLGBTCG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50105619   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50105619(1-(5-tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)u...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50105619(1-(5-tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)u...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Raf-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50105619(1-(5-tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)u...)
Affinity DataIC50: 360nMAssay Description:Inhibition of Escherichia coli derived Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50105619(1-(5-tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)u...)
Affinity DataIC50: 540nMAssay Description:Inhibitory concentration against raf kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50105619(1-(5-tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)u...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed