BDBM50106018 (7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide::CHEMBL99120

SMILES CNC(=O)[C@@H]1Cc2ccc(OCCCC[C@@H]([C@@H](CCCc3cc(OC)ccc3OC)C(=O)N1)C(=O)NO)cc2

InChI Key InChIKey=LBQUSUPCYKIDFL-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50106018   

LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 6.80nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 140nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 141nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 4.10E+3nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed