BDBM50106020 CHEMBL99109::N-Hydroxy-2-methyl-3-[4-(3,4,5-trimethoxy-phenoxy)-phenylsulfanyl]-propionamide

SMILES COc1cc(Oc2ccc(SCC(C)C(=O)NO)cc2)cc(OC)c1OC

InChI Key InChIKey=TZTMRGAOGRZNKP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50106020   

LigandPNGBDBM50106020(N-Hydroxy-2-methyl-3-[4-(3,4,5-trimethoxy-phenoxy)...)
Affinity DataIC50: 180nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106020(N-Hydroxy-2-methyl-3-[4-(3,4,5-trimethoxy-phenoxy)...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106020(N-Hydroxy-2-methyl-3-[4-(3,4,5-trimethoxy-phenoxy)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed