BDBM50106021 (7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide::CHEMBL99283

SMILES CNC(=O)[C@@H]1Cc2ccc(OCCCC[C@@H]([C@@H](CCCc3cc(C)cc(c3)C(C)C)C(=O)N1)C(=O)NO)cc2

InChI Key InChIKey=YINOLIYDTHQXKP-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50106021   

LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 12nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 13nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 96nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 96nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 200nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 220nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 220nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed