BDBM50106024 (7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide::CHEMBL99547

SMILES Cc1ccc(CCC[C@@H]2[C@H](CCCCOc3ccc(C[C@H](NC2=O)C(=O)c2ccccc2)cc3)C(=O)NO)cc1

InChI Key InChIKey=GIGQELYOVAVUIF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50106024   

Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 96nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 96nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 320nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 324nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed