BDBM50106025 (S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid hydroxyamide::(S)-N-hydroxy-2,2-dimethyl-4-(4-(3,4,5-trimethoxyphenoxy)phenylsulfonyl)thiomorpholine-3-carboxamide::CHEMBL95305

SMILES COc1cc(Oc2ccc(cc2)S(=O)(=O)N2CCSC(C)(C)[C@@H]2C(=O)NO)cc(OC)c1OC

InChI Key InChIKey=DCDJWNFOPNVBIM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50106025   

LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 1.5nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 21nMAssay Description:Inhibition against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 26nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 501nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 550nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 550nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed