BDBM50106029 (7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide::CHEMBL98304

SMILES ONC(=O)[C@H]1CCCCOc2ccc(C[C@H](NC(=O)[C@@H]1CCCc1cc(Br)cc(Br)c1)C(=O)c1ccccc1)cc2

InChI Key InChIKey=IGKZHEJCICMYIH-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50106029   

LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 79nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 87nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 87nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 229nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 230nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 5.00E+3nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 9.12E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed