BDBM50106031 (7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethoxy-phenyl)-propyl]-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide::CHEMBL329232

SMILES COc1cc(CCC[C@@H]2[C@H](CCCCOc3ccc(C[C@H](NC2=O)C(=O)c2ccccc2)cc3)C(=O)NO)cc(OC)c1OC

InChI Key InChIKey=HKZHDTJNCBXYPY-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50106031   

LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 50nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 50.1nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 55nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 55nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 3.50E+3nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed