BDBM50106660 (2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl}-2-{(1S)-1--[formyl(hydroxy)amino]-2-phenylethyl}-4-methylpentanamide::CHEMBL337512

SMILES CC(C)C[C@H]([C@H](Cc1ccccc1)N(O)C=O)C(=O)N[C@@H](CCCN=C(N)N[N+]([O-])=O)C(=O)Nc1nccs1

InChI Key InChIKey=HDTMIVHMPQVMJD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50106660   

TargetMatrix metalloproteinase-9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50106660((2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-yl...)
Affinity DataIC50: 11nMAssay Description:Inhibition potency was determined by fluorescence-based peptide assay against matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106660((2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-yl...)
Affinity DataIC50: 49nMAssay Description:Inhibition of TACE using scintillation proximity assay (SPA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50106660((2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-yl...)
Affinity DataIC50: 26nMAssay Description:Inhibition potency was determined by fluorescence-based peptide assay against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50106660((2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-yl...)
Affinity DataIC50: 31nMAssay Description:Inhibition potency was determined by fluorescence-based peptide assay against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed