BDBM50106661 (2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl}-3-[formyl(hydroxy)amino]-2-[(5-methyl-2-thienyl)methyl]hexanamide::CHEMBL135075

SMILES CCC[C@@H]([C@@H](Cc1ccc(C)s1)C(=O)N[C@@H](CCCN=C(N)N[N+]([O-])=O)C(=O)Nc1nccs1)N(O)C=O

InChI Key InChIKey=JEFVBTZAXMPPTH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50106661   

TargetMatrix metalloproteinase-9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50106661((2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-yl...)
Affinity DataIC50: 190nMAssay Description:Inhibition potency was determined by fluorescence-based peptide assay against matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50106661((2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-yl...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition potency was determined by fluorescence-based peptide assay against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106661((2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-yl...)
Affinity DataIC50: 9nMAssay Description:Inhibition of TACE using scintillation proximity assay (SPA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50106661((2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-yl...)
Affinity DataIC50: 79nMAssay Description:Inhibition potency was determined by fluorescence-based peptide assay against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed