BDBM50107214 1-(1-Benzyl-piperidin-4-yl)-3-naphthalen-1-yl-urea::CHEMBL137041::US11116757, No. B39

SMILES O=C(NC1CCN(Cc2ccccc2)CC1)Nc1cccc2ccccc12

InChI Key InChIKey=BVQQWGYSPFFTBU-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50107214   

TargetSigma non-opioid intracellular receptor 1(Human)
Wake Forest University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50107214(1-(1-Benzyl-piperidin-4-yl)-3-naphthalen-1-yl-urea...)
Affinity DataKi:  22.7nMAssay Description:Binding affinity for sigma 1 opioid receptor, measured on guinea pig brain membranes using [3H]- (+)-pentazocine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Human)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50107214(1-(1-Benzyl-piperidin-4-yl)-3-naphthalen-1-yl-urea...)
Affinity DataIC50: 6.18E+4nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent