BDBM50107633 3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-benzoic acid::CHEMBL336228

SMILES Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](COCc2cccc(c2)C(O)=O)C#N)c1

InChI Key InChIKey=NLBSRGTVALONBM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50107633   

TargetCathepsin B(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against recombinant human cathepsin L (cat L) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 46nMAssay Description:Inhibitory activity against recombinant human cathepsin S (cat S) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed