BDBM50108306 (S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine::(S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamine::CHEMBL40726

SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12

InChI Key InChIKey=MYZDBEVPJGKIQS-UHFFFAOYSA-N

Data  12 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50108306   

Target5-hydroxytryptamine receptor 2C(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataEC50:  200nMAssay Description:Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of North Texas Health Science Center

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]mesulergine from human cloned 5HT2C receptor expressed in HEK293 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of North Texas Health Science Center

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  1nMAssay Description:Binding affinity against human 5-hydroxytryptamine 2C receptor using displacement of [3H]DOBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of North Texas Health Science Center

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  3.80nMAssay Description:Tested for binding affinity towards human 5-hydroxytryptamine 2C receptor using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of North Texas Health Science Center

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  3.90nMAssay Description:Tested for binding affinity towards human 5-hydroxytryptamine 2C receptor using [3H]DOB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  12nMAssay Description:Tested for binding affinity towards human 5-hydroxytryptamine 2A receptor using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  15nMAssay Description:Tested for binding affinity towards rat 5-hydroxytryptamine 2A receptor using [3H]DOB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  39nMAssay Description:Tested for binding affinity towards human 5-hydroxytryptamine 2A receptor using [3H]DOB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of North Texas Health Science Center

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  85nMAssay Description:Tested for binding affinity towards human 5-hydroxytryptamine 2C receptor using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of North Texas Health Science Center

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  85nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 2C receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]methylspiperone from human cloned 5HT2A receptor expressed in HEK293 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  100nMAssay Description:Binding affinity against human 5-hydroxytryptamine 2A receptor using displacement of [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50108306((S)-2-(5,6-Difluoro-indol-1-yl)-1-methyl-ethylamin...)
Affinity DataKi:  320nMAssay Description:Tested for binding affinity towards rat 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed