BDBM50108448 1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one::CHEMBL280037

SMILES FC(F)(F)c1ccc(cc1)-c1cccn(C(CN2CCCC2)c2ccccc2)c1=O

InChI Key InChIKey=FEBHFORUGPWOLH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50108448   

TargetKappa-type opioid receptor(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50108448(1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluor...)
Affinity DataIC50: 8.70nMAssay Description:Binding affinity towards kappa opioid receptor by the displacement of [125I]-(D-Pro10)-Dynorphin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50108448(1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluor...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of [125I]-(D-Pro10)-Dynorphin A binding to human kappa opioid receptor from membranes of HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50108448(1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluor...)
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of [125I]Enkephalin binding to human mu opioid receptor from membranes of HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50108448(1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluor...)
Affinity DataIC50: 2.72E+3nMAssay Description:Binding affinity towards mu opioid receptor by the displacement of [125I]EnkephalinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50108448(1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluor...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity towards Opioid receptor delta 1 by the displacement of [125I]-DeltorphinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50108448(1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluor...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of [125I]deltorphin binding to human delta opioid receptor from membranes of HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed