BDBM50110169 CHEMBL2218113

SMILES Clc1cccc(C(=O)N2CCn3c(C2)nnc3-c2cnccn2)c1Cl

InChI Key InChIKey=AXQZZNUTSSFRSV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50110169   

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50110169(CHEMBL2218113)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of BzATP-induced Ca2+ flux after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50110169(CHEMBL2218113)
Affinity DataIC50: 10nMAssay Description:Antagonist activity against human P2X7 receptor expressed in HEK293 cells by FLIPR based calcium accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50110169(CHEMBL2218113)
Affinity DataIC50: 3.32E+3nMAssay Description:Antagonist activity at rat P2X7 receptor assessed as inhibition of ATP-induced Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed