BDBM50112355 CHEMBL3609326

SMILES CCN1c2c(cnc(n2)Nc3ccc(c(c3)F)N4CCNCC4)C=C(C1=O)c5ccc(cc5Cl)Cl

InChI Key InChIKey=DHKFOIHIUYFSOF-UHFFFAOYSA-N

Data  21 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50112355   

TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 32nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 779nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 779nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 3(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 779nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 3(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 8.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 779nMAssay Description:Inhibition of full length PAK4 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 513nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 245nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of full length PAK1 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 40nMAssay Description:Inhibition of full length PAK2 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 55nMAssay Description:Inhibition of full length PAK3 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed