BDBM50112383 17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22,5.114,18.08,12.023,27]hentriaconta-1(27),8,10,14(31),15,17,20(28),21,23,25-decaen-3-one::CHEMBL23650

SMILES FC(F)(F)CCCCc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34

InChI Key InChIKey=PHGAACKWQSAJHR-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50112383   

LigandPNGBDBM50112383(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Affinity DataIC50: 60nMAssay Description:Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]GGPP into a biotinylated peptide corresponding to the C-term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112383(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Affinity DataEC50:  6.90nMAssay Description:Inhibition of HDJ2 farnesylation in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112383(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Affinity DataEC50:  800nMAssay Description:Inhibition of geranylgeranylation of Rap1a in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112383(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Affinity DataIC50: 0.480nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112383(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed