BDBM50113662 1-(2,3-Dichloro-phenyl)-1H-[1,2,4]triazole-3-carboxylic acid {1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-amide::CHEMBL80508

SMILES COc1ccc(NCCNC(=O)[C@H](CC(C)C)NC(=O)c2ncn(n2)-c2cccc(Cl)c2Cl)cc1

InChI Key InChIKey=JQNHXIBBQPRXPC-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50113662   

TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50113662(1-(2,3-Dichloro-phenyl)-1H-[1,2,4]triazole-3-carbo...)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human cathepsin K in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50113662(1-(2,3-Dichloro-phenyl)-1H-[1,2,4]triazole-3-carbo...)
Affinity DataKi:  11nMAssay Description:Eq. constant (Ki) for inhibition of Cathepsin K was determined by progress curves, following hydrolysis of Z-Phe-Arg- Amc in the absence and presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50113662(1-(2,3-Dichloro-phenyl)-1H-[1,2,4]triazole-3-carbo...)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human cathepsin S in a fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50113662(1-(2,3-Dichloro-phenyl)-1H-[1,2,4]triazole-3-carbo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human cathepsin L in a fluorescence assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed