BDBM50114435 2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL297251

SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1C#N

InChI Key InChIKey=QNHKZDQLUUKJBH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50114435   

TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114435(2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114435(2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114435(2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 1.10E+4nMAssay Description:Tested for the binding affinity against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114435(2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against tissue plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114435(2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114435(2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114435(2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed