BDBM50115021 1-(3-Cyano-phenyl)-3-{3-[4-(4-fluoro-benzyl)-piperidin-1-yl]-propyl}-urea::CHEMBL43677

SMILES Fc1ccc(CC2CCN(CCCNC(=O)Nc3cccc(c3)C#N)CC2)cc1

InChI Key InChIKey=JHJVGMKZQAABON-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50115021   

TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115021(1-(3-Cyano-phenyl)-3-{3-[4-(4-fluoro-benzyl)-piper...)
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115021(1-(3-Cyano-phenyl)-3-{3-[4-(4-fluoro-benzyl)-piper...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115021(1-(3-Cyano-phenyl)-3-{3-[4-(4-fluoro-benzyl)-piper...)
Affinity DataIC50: 80nMAssay Description:In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115021(1-(3-Cyano-phenyl)-3-{3-[4-(4-fluoro-benzyl)-piper...)
Affinity DataKi:  167nMAssay Description:Inhibition of [125I]-eotaxin binding to serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed