BDBM50117099 CHEMBL3613118::US9365534, HU-308

SMILES [H][C@@]12C[C@@]([H])(C(CO)=C[C@H]1c1c(OC)cc(cc1OC)C(C)(C)CCCCCC)C2(C)C

InChI Key

Data  2 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50117099   

TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50117099(CHEMBL3613118 | US9365534, HU-308)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor transfected in HEK293EBNA cell membranes after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50117099(CHEMBL3613118 | US9365534, HU-308)
Affinity DataKi:  14nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:The Kd of CP 55,940 in the isolated CB1 and CB2 receptor expressing membranes was previously determined to be 2.3 nM and 1.5 nM, respectively (see Pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50117099(CHEMBL3613118 | US9365534, HU-308)
Affinity DataEC50:  18.3nMpH: 7.5Assay Description:Human CB2 expressing CHO-K1 membranes (5 μg per incubation mixture) were diluted in 50 mM Tris-HCl (pH 7.5) and 0.5 mM EDTA and added to HU comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50117099(CHEMBL3613118 | US9365534, HU-308)
Affinity DataIC50: 117nMpH: 7.5 T: 2°CAssay Description:Cells were seeded at a density of 10,000 cells per well in poly-L-lysine treated 96-well culture plates (BD Biosciences). The following day wells wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent