BDBM50117799 CHEMBL327705::N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-benzylsulfanyl)-5-(1-methyl-1H-pyrazol-4-ylmethyl)-4-oxo-4H-pyrimidin-1-yl]-N-[3-(4-methyl-piperazin-1-yl)-propyl]-acetamide

SMILES CN1CCN(CCCN(Cc2ccc(cc2)-c2ccc(Cl)cc2)C(=O)Cn2cc(Cc3cnn(C)c3)c(=O)nc2SCc2ccc(F)cc2)CC1

InChI Key InChIKey=UYBIRMFTNJZIJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50117799   

TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117799(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-b...)
Affinity DataIC50: 2nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117799(N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-b...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cytochrome P450 3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed