BDBM50118070 (Z)-Gugglesterone::Guggulsterone

SMILES [H][C@@]12CC(=O)\C(=C/C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

InChI Key InChIKey=WDXRGPWQVHZTQJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50118070   

TargetBile acid receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50118070((Z)-Gugglesterone | Guggulsterone)
Affinity DataIC50: 8.94E+4nMAssay Description:Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of CDCA-induced Bio-SRC-1 recruitment after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2016
Entry Details Article
PubMed
TargetBile acid receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50118070((Z)-Gugglesterone | Guggulsterone)
Affinity DataIC50: 4.49E+4nMAssay Description:Inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment in GST-tagged FXR LBD (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50118070((Z)-Gugglesterone | Guggulsterone)
Affinity DataIC50: 7.44E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed