BDBM50118263 5-(4-Chloro-phenyl)-7-methoxy-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol::CHEMBL132082

SMILES COc1ccc2C3=NCCN3C(O)(c2c1)c1ccc(Cl)cc1

InChI Key InChIKey=LCWPWPFSABPKJM-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50118263   

TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50118263(5-(4-Chloro-phenyl)-7-methoxy-2,5-dihydro-3H-imida...)
Affinity DataIC50: 1.46nMAssay Description:Inhibition of NE uptake in HEK cells expressing human noradrenaline transporter (hNET)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50118263(5-(4-Chloro-phenyl)-7-methoxy-2,5-dihydro-3H-imida...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]- RTI-55 from Dopamine transporter expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50118263(5-(4-Chloro-phenyl)-7-methoxy-2,5-dihydro-3H-imida...)
Affinity DataIC50: 13.3nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine Transporter of guinea pig striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50118263(5-(4-Chloro-phenyl)-7-methoxy-2,5-dihydro-3H-imida...)
Affinity DataIC50: 16.7nMAssay Description:Inhibition of dopamine uptake in HEK cells expressing human dopamine transporter (hDAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50118263(5-(4-Chloro-phenyl)-7-methoxy-2,5-dihydro-3H-imida...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]RTI-55 from human Norepinephrine transporter expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50118263(5-(4-Chloro-phenyl)-7-methoxy-2,5-dihydro-3H-imida...)
Affinity DataKi:  1.03E+3nMAssay Description:Displacement of [125I]- RTI-55 from Serotonin transporter expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50118263(5-(4-Chloro-phenyl)-7-methoxy-2,5-dihydro-3H-imida...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of 5-HT uptake in HEK cells expressing human serotonin transporter (hSERT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed