BDBM50118979 4-(4-But-2-ynyloxy-benzenesulfonyl)-1-cyclopropanecarbonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide::CHEMBL95460

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N1Cc2ccccc2N(CC1C(=O)NO)C(=O)C1CC1

InChI Key InChIKey=BLQAAMGUGMNRQN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50118979   

LigandPNGBDBM50118979(4-(4-But-2-ynyloxy-benzenesulfonyl)-1-cyclopropane...)
Affinity DataIC50: 10nMAssay Description:Concentration required in vitro to inhibit TNF-alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118979(4-(4-But-2-ynyloxy-benzenesulfonyl)-1-cyclopropane...)
Affinity DataIC50: 29nMAssay Description:Concentration required in vitro to inhibit Matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118979(4-(4-But-2-ynyloxy-benzenesulfonyl)-1-cyclopropane...)
Affinity DataIC50: 33nMAssay Description:Concentration required in vitro to inhibit Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118979(4-(4-But-2-ynyloxy-benzenesulfonyl)-1-cyclopropane...)
Affinity DataIC50: 841nMAssay Description:Concentration required in vitro to inhibit Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed