BDBM50119244 2-[2-(Isoquinolin-5-yloxy)-acetylamino]-4-methyl-pentanoic acid (2-hydroxy-5-oxo-tetrahydro-furan-3-yl)-amide::CHEMBL101684

SMILES CC(C)C[C@H](NC(=O)COc1cccc2cnccc12)C(=O)N[C@H]1CC(=O)OC1O

InChI Key InChIKey=QFKHZABETHFMHQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50119244   

TargetCaspase-7(Human)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119244(2-[2-(Isoquinolin-5-yloxy)-acetylamino]-4-methyl-p...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibitory concentration against caspase-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119244(2-[2-(Isoquinolin-5-yloxy)-acetylamino]-4-methyl-p...)
Affinity DataIC50: 3.64E+3nMAssay Description:Inhibitory concentration against caspase-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-1(Human)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119244(2-[2-(Isoquinolin-5-yloxy)-acetylamino]-4-methyl-p...)
Affinity DataIC50: 5.14E+3nMAssay Description:Inhibition of caspase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-6(Human)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119244(2-[2-(Isoquinolin-5-yloxy)-acetylamino]-4-methyl-p...)
Affinity DataIC50: 4.27E+4nMAssay Description:Inhibitory concentration required against caspase-6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119244(2-[2-(Isoquinolin-5-yloxy)-acetylamino]-4-methyl-p...)
Affinity DataIC50: 407nMAssay Description:Inhibitory concentration against caspase-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed